Extensively refurbished, the Heart and Lung Centre is located at 20 Queen Anne Street in  central London.  Behind an elegant period façade, the Heart and Lung Centre is a modern clinic occupying a prominent location at the heart of the Howard de Walden Estate, providing approximately 11,000 sq. ft. (1022 sq. m.) of comfort cooled offices over five floors.

Located on the north side of Queen Anne Street close to its junction with Harley Street, the Heart and Lung Centre is moments away from Marylebone High Street which was recently voted the country's favourite London street, in a national independent survey carried out by CABE for BBC Radio 4.  Bond Street and Oxford Circus underground stations are within easy walking distance (Central, Jubilee, Bakerloo and Victoria lines). Mainline stations at Marylebone, Paddington (Heathrow Express), Euston, Kings Cross and St. Pancras are also easily accessible.